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MOTS-C

from $300.00

MOTS-c is a mitochondrial-derived peptide (a small signaling peptide encoded by mitochondrial DNA) that has been studied for its role in metabolic flexibility, insulin sensitivity pathways, and cellular stress adaptation—often described in research as an “exercise-mimetic” signal.

Duration:

MOTS-c is a mitochondrial-derived peptide (a small signaling peptide encoded by mitochondrial DNA) that has been studied for its role in metabolic flexibility, insulin sensitivity pathways, and cellular stress adaptation—often described in research as an “exercise-mimetic” signal.

Supply Duration: 35 Day or 105 Day Supply
Standard Dosing Protocol: 400 mcg (5 days on, 2 days off)
This is standard protocol. The provider has the ability to change protocol based on their medical expertise.

What’s Included: 

  • 1 or 3-Month Supply

  • Medical Expertise & Guidance

  • Prescription grade, from a U.S. Licensed Compound Pharmacy

  • Reconstituted and ready-to-use

  • Syringes, supplies and instructions included

  • Free Expedited Shipping

MOTS-C is explored for its energy and metabolic benefits, which may include:

  • Metabolic flexibility support (how efficiently the body uses fuel) 

  • Insulin sensitivity support (studied heavily in metabolic models) 

  • Mitochondrial function & cellular energy support (mitochondrial signaling peptide) 

  • Performance / recovery support (often positioned as “exercise signaling”) 

Contraindications and exclusions

  • Pregnancy and breastfeeding (insufficient human safety data)

  • Known allergy or hypersensitivity to MOTS-C or components

  • Active cancer or unclear cancer history—route to prescribing provider

  • Concomitant metabolic agents (e.g., strong AMPK-modulating drugs); provider to monitor and decide

Clinical & Research References for MOTS-c

  • Lee C, et al. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance (preclinical). Cell (full text). https://www.cell.com/article/S1550-4131%2815%2900061-3/fulltext 

  • Kim SJ, et al. The mitochondrial-derived peptide MOTS-c is an exercise mimetic and improves insulin sensitivity in aged and diet-induced obese mice. Physiological Reports (Wiley). https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.14171 

  • Zheng Y, et al. MOTS-c: A promising mitochondrial-derived peptide… (review of mechanisms + current evidence landscape). PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC9905433/ 

  • Domin R, et al. MOTS-c serum concentration correlates with lower-body muscle strength… (human observational data). Int. J. Mol. Sci. (MDPI). https://www.mdpi.com/1422-0067/24/19/14951 

Prescription products require an online evaluation by a licensed medical professional. Medications are prescribed by licensed physicians as part of our programs, and actual product packaging may vary. The FDA does not review compounded medications for safety or effectiveness.

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